The Integrative Human Microbiome Project

被引：923

作者：

Proctor, Lita M. ^{[1
,13
]}

Creasy, Heather H. ^{[2
,13
]}

Fettweis, Jennifer M. ^{[3
,4
,5
]}

Lloyd-Price, Jason ^{[6
,7
]}

Mahurkar, Anup ^{[2
]}

Zhou, Wenyu ^{[8
]}

Buck, Gregory A. ^{[3
,5
,9
]}

Snyder, Michael P. ^{[8
,10
,11
]}

Strauss, Jerome F., III ^{[4
,5
]}

Weinstock, George M. ^{[12
]}

White, Owen ^{[2
]}

Huttenhower, Curtis ^{[6
,7
,13
]}

机构：

[1] NHGRI, NIH, Bethesda, MD 20892 USA

[2] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA

[3] Virginia Commonwealth Univ, Dept Microbiol & Immunol, Sch Med, Richmond, VA 23298 USA

[4] Virginia Commonwealth Univ, Dept Obstet & Gynecol, Sch Med, Med Coll Virginia Campus, Richmond, VA 23284 USA

[5] Virginia Commonwealth Univ, Ctr Microbiome Engn & Data Anal, Med Coll Virginia Campus, Richmond, VA 23284 USA

[6] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[7] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[8] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA

[9] Virginia Commonwealth Univ, Dept Comp Sci, Coll Engn, Med Coll Virginia Campus, Richmond, VA 23284 USA

[10] Stanford Ctr Genom & Personalized Med, Stanford, CA 94305 USA

[11] Stanford Diabet Res Ctr, Stanford, CA 94305 USA

[12] Jackson Lab Genom Med, Farmington, CT 06032 USA

[13] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

NATURE | 2019年 / 569卷 / 7758期

关键词：

INFLAMMATORY-BOWEL-DISEASE; HUMAN GUT MICROBIOME; VAGINAL MICROBIOME; FECAL MICROBIOTA; CROHNS-DISEASE; BODY HABITATS; DIVERSITY; METAANALYSIS; MORTALITY; PROFILES;

D O I：

10.1038/s41586-019-1238-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The NIH Human Microbiome Project (HMP) has been carried out over ten years and two phases to provide resources, methods, and discoveries that link interactions between humans and their microbiomes to health-related outcomes. The recently completed second phase, the Integrative Human Microbiome Project, comprised studies of dynamic changes in the microbiome and host under three conditions: pregnancy and preterm birth; inflammatory bowel diseases; and stressors that affect individuals with prediabetes. The associated research begins to elucidate mechanisms of host-microbiome interactions under these conditions, provides unique data resources (at the HMP Data Coordination Center), and represents a paradigm for future multi-omic studies of the human microbiome.

引用

页码：641 / 648

页数：8

共 89 条

[1]

The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters [J].

Aagaard, Kjersti ;

Petrosino, Joseph ;

Keitel, Wendy ;

Watson, Mark ;

Katancik, James ;

Garcia, Nathalia ;

Patel, Shital ;

Cutting, Mary ;

Madden, Tessa ;

Hamilton, Holli ;

Harris, Emily ;

Gevers, Dirk ;

Simone, Gina ;

McInnes, Pamela ;

Versalovic, James .

FASEB JOURNAL, 2013, 27 (03) :1012-1022

[2]

Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome [J].

Abubucker, Sahar ;

Segata, Nicola ;

Goll, Johannes ;

Schubert, Alyxandria M. ;

Izard, Jacques ;

Cantarel, Brandi L. ;

Rodriguez-Mueller, Beltran ;

Zucker, Jeremy ;

Thiagarajan, Mathangi ;

Henrissat, Bernard ;

White, Owen ;

Kelley, Scott T. ;

Methe, Barbara ;

Schloss, Patrick D. ;

Gevers, Dirk ;

Mitreva, Makedonka ;

Huttenhower, Curtis .

PLOS COMPUTATIONAL BIOLOGY, 2012, 8 (06)

[3]

Community differentiation of the cutaneous microbiota in psoriasis [J].

Alekseyenko, Alexander V. ;

Perez-Perez, Guillermo I. ;

De Souza, Aieska ;

Strober, Bruce ;

Gao, Zhan ;

Bihan, Monika ;

Li, Kelvin ;

Methe, Barbara A. ;

Blaser, Martin J. .

MICROBIOME, 2013, 1

[4]

[Anonymous], 2006, PRETERM BIRTH CAUSES

[5]

Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin [J].

Brown, Richard G. ;

Marchesi, Julian R. ;

Lee, Yun S. ;

Smith, Ann ;

Lehne, Benjamin ;

Kindinger, Lindsay M. ;

Terzidou, Vasso ;

Holmes, Elaine ;

Nicholson, Jeremy K. ;

Bennett, Phillip R. ;

MacIntyre, David A. .

BMC MEDICINE, 2018, 16

[6]

Replication and refinement of a vaginal microbial signature of preterm birth in two racially distinct cohorts of US women [J].

Callahan, Benjamin J. ;

DiGiulio, Daniel B. ;

Goltsman, Daniela S. Aliaga ;

Sun, Christine L. ;

Costello, Elizabeth K. ;

Jeganathan, Pratheepa ;

Biggio, Joseph R. ;

Wong, Ronald J. ;

Druzin, Maurice L. ;

Shaw, Gary M. ;

Stevenson, David K. ;

Holmes, Susan P. ;

Relman, David A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (37) :9966-9971

[7]

Complex Carbohydrate Utilization by the Healthy Human Microbiome [J].

Cantarel, Brandi L. ;

Lombard, Vincent ;

Henrissat, Bernard .

PLOS ONE, 2012, 7 (06)

[8]

Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes [J].

Chen, Rui ;

Mias, George I. ;

Li-Pook-Than, Jennifer ;

Jiang, Lihua ;

Lam, Hugo Y. K. ;

Chen, Rong ;

Miriami, Elana ;

Karczewski, Konrad J. ;

Hariharan, Manoj ;

Dewey, Frederick E. ;

Cheng, Yong ;

Clark, Michael J. ;

Im, Hogune ;

Habegger, Lukas ;

Balasubramanian, Suganthi ;

O'Huallachain, Maeve ;

Dudley, Joel T. ;

Hillenmeyer, Sara ;

Haraksingh, Rajini ;

Sharon, Donald ;

Euskirchen, Ghia ;

Lacroute, Phil ;

Bettinger, Keith ;

Boyle, Alan P. ;

Kasowski, Maya ;

Grubert, Fabian ;

Seki, Scott ;

Garcia, Marco ;

Whirl-Carrillo, Michelle ;

Gallardo, Mercedes ;

Blasco, Maria A. ;

Greenberg, Peter L. ;

Snyder, Phyllis ;

Klein, Teri E. ;

Altman, Russ B. ;

Butte, Atul J. ;

Ashley, Euan A. ;

Gerstein, Mark ;

Nadeau, Kari C. ;

Tang, Hua ;

Snyder, Michael .

CELL, 2012, 148 (06) :1293-1307

[9]

Bacterial Community Variation in Human Body Habitats Across Space and Time [J].

Costello, Elizabeth K. ;

Lauber, Christian L. ;

Hamady, Micah ;

Fierer, Noah ;

Gordon, Jeffrey I. ;

Knight, Rob .

SCIENCE, 2009, 326 (5960) :1694-1697

[10]

Full Accounting of Diabetes and Pre-Diabetes in the US Population in 1988-1994 and 2005-2006 [J].

Cowie, Catherine C. ;

Rust, Keith F. ;

Ford, Earl. S. ;

Eberhardt, Mark S. ;

Byrd-Holt, Danita D. ;

Li, Chaoyang ;

Williams, Desmond E. ;

Gregg, Edward W. ;

Bainbridge, Kathleen E. ;

Saydah, Sharon H. ;

Geiss, Linda S. .

DIABETES CARE, 2009, 32 (02) :287-294

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