The roles of corticotropin-releasing factor-related peptides and their receptors in the cardiovascular system

被引：16

作者：

Nazarloo, Hossein Pournajafi

Buttrick, P. M.

Saadat, H.

Dunn, A. J.

机构：

[1] Univ Illinois, Dept Psychiat, Brain Body Ctr, Chicago, IL 60612 USA

[2] Univ Illinois, Coll Med, Dept Cardiol, Chicago, IL 60612 USA

[3] Univ Ottawa, Inst Heart, Ottawa, ON, Canada

[4] Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol & Therapeut, Shreveport, LA 71130 USA

来源：

CURRENT PROTEIN & PEPTIDE SCIENCE | 2006年 / 7卷 / 03期

关键词：

CRF; urocortin; cardiovascular; stress;

D O I：

10.2174/138920306777452358

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Corticotropin-releasing factor (CRF), CRF-related peptides and their receptors are present in the central nervous system and in peripheral tissues including the immune, reproductive and cardiovascular systems. CRF and urocortin (urocortin 1) bind to the CRF receptor type 1 (CRF1 receptor) and the CRF receptor type 2 (CRF2 receptor), whereas urocortin 2 (formerly known as stresscopin related peptide) and urocortin 3 (formerly known as stresscopin) bind with high affinity to the CRF2 receptor. Recent studies show that urocortin 1. urocortin 2 and urocortin 3 are potent regulators of cardiovascular function. This review highlights the role of cardiovascular CRF and related peptides and its relevance in mediating the adaptive response of the cardiovascular system to stressful conditions.

引用

收藏

页码：229 / 239

页数：11

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