Synthesis of Macrocyclic β-Strand Templates by Ring Closing Metathesis

被引：39

作者：

Abell, Andrew D. ^{[1
]}

Alexander, Nathan A. ^{[1
]}

Aitken, Steven G. ^{[1
]}

Chen, Hongyuan ^{[1
]}

Coxon, James M. ^{[1
]}

Jones, Matthew A. ^{[1
]}

McNabb, Stephen B. ^{[1
]}

Muscroft-Taylor, Andrew ^{[1
]}

机构：

[1] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 11期

基金：

澳大利亚研究理事会;

关键词：

D O I：

10.1021/jo802723w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the synthesis of macrocycles 1-6 via ring closing metathesis of dienes 7-12. Addition of chlorodicyclohexylborane to thermal and microwave assisted RCM of dienes 8 and 9 markedly improves the yield. The geometric isomers of macrocycles 1-3 and 5 have been assigned using X-ray crystallography and NMR.

引用

页码：4354 / 4356

页数：3

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