Molecular mechanisms of nickel carcinogenesis

被引：23

作者：

Costa, M ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Environm Med, Tuxedo Pk, NY 10987 USA

来源：

BIOLOGICAL CHEMISTRY | 2002年 / 383卷 / 06期

关键词：

chromosome damage; gene silencing; heterochromatin;

D O I：

10.1515/BC.2002.102

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A brief review of the molecular mechanisms of nickel carcinogenesis is presented. Molecular mechanisms of nickel carcinogenesis are considered from the pointofview of nickelinduced gene silencing by DNA hypermethylation in mammalian cells and by its ability to inhibit histone acetylation. Model systems designed to study the molecular mechanism of gene silencing are discussed.

引用

页码：961 / 967

页数：7

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