Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus

被引：180

作者：

Kim, J

Alger, BE

机构：

[1] Univ Maryland, Sch Med, Program Neurosci, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA

来源：

NATURE NEUROSCIENCE | 2004年 / 7卷 / 07期

关键词：

D O I：

10.1038/nn1262

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In hippocampal pyramidal cells, a rise in Ca2+ releases endocannabinoids that activate the presynaptic cannabinoid receptor (CB1R) and transiently reduce GABAergic transmission-a process called depolarization-induced suppression of inhibition (DSI). The mechanism that limits the duration of endocannabinoid action in intact cells is unknown. Here we show that inhibition of cyclooxygenase-2 (COX-2), not fatty acid amide hydrolase (FAAH), prolongs DSI, suggesting that COX-2 limits endocannabinoid action.

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页码：697 / 698

页数：2

相关论文

共 14 条

[1]

Alger BE, 2002, PROG NEUROBIOL, V68, P247

[2] Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity [J].

Chen, C ;

Magee, JC ;

Bazan, NG .

JOURNAL OF NEUROPHYSIOLOGY, 2002, 87 (06) :2851-2857

[3] Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides [J].

Cravatt, BF ;

Giang, DK ;

Mayfield, SP ;

Boger, DL ;

Lerner, RA ;

Gilula, NB .

NATURE, 1996, 384 (6604) :83-87

[4] ENZYMATIC-SYNTHESIS AND DEGRADATION OF ANANDAMIDE, A CANNABINOID RECEPTOR AGONIST [J].

DEUTSCH, DG ;

CHIN, SA .

BIOCHEMICAL PHARMACOLOGY, 1993, 46 (05) :791-796

[5] Brain monoglyceride lipase participating in endocannabinoid inactivation [J].

Dinh, TP ;

Carpenter, D ;

Leslie, FM ;

Freund, TF ;

Katona, I ;

Sensi, SL ;

Kathuria, S ;

Piomelli, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (16) :10819-10824

[6]

Fowler CJ, 1997, J PHARMACOL EXP THER, V283, P729

[7] Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors [J].

Goparaju, SK ;

Ueda, N ;

Taniguchi, K ;

Yamamoto, S .

BIOCHEMICAL PHARMACOLOGY, 1999, 57 (04) :417-423

[8] A role for endocannabinoids in indomethacin-induced spinal antinociception [J].

Gühring, H ;

Hamza, M ;

Sergejeva, M ;

Ates, M ;

Kotalla, CE ;

Ledent, C ;

Brune, K .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 454 (2-3) :153-163

[9] Modulation of anxiety through blockade of anandamide hydrolysis [J].

Kathuria, S ;

Gaetani, S ;

Fegley, D ;

Valiño, F ;

Duranti, A ;

Tontini, A ;

Mor, M ;

Tarzia, G ;

La Rana, G ;

Calignano, A ;

Giustino, A ;

Tattoli, M ;

Palmery, M ;

Cuomo, V ;

Piomelli, D .

NATURE MEDICINE, 2003, 9 (01) :76-81

[10] COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex [J].

Kaufmann, WE ;

Worley, PF ;

Pegg, J ;

Bremer, M ;

Isakson, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) :2317-2321