Spectrophotometric assessment of pigmented skin lesions: methods and feature selection for evaluation of diagnostic performance

被引:101
作者
Wallace, VP [1 ]
Crawford, DC
Mortimer, PS
Ott, RJ
Bamber, JC
机构
[1] Inst Canc Res, Dept Phys, Sutton SM2 5PT, Surrey, England
[2] Inst Canc Res, Dept Dermatol, Sutton SM2 5PT, Surrey, England
[3] Royal Marsden NHS Trust, Sutton SM2 5PT, Surrey, England
关键词
D O I
10.1088/0031-9155/45/3/312
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
This study documents the optical reflectance characteristics of pigmented skin lesions and evaluates their potential For improving the differential diagnosis of malignant melanoma from benign pigmented skin lesions. Optical reflectance spectra in the wavelength range 320-1100 nm were obtained from 121 lesions already selected by expert dermatologists as suspicious of malignancy. Characteristic differences in spectra from benign and malignant lesions were studied. Feature extraction showed significant differences between lesion groups classified by histology. Seven of the most relevant features were used in the discriminant analysis of reflectance spectra from 15 melanoma and 32 compound naevi which resulted in a sensitivity of 100% and specificity of 84.4% when compared with histology. This simple objective technique appears to perform as well as the expert dermatologist and may improve the diagnostic accuracy of non-specialists such as trainees and GPs. Further prospective clinical study of reflectance spectrophotometry in a larger patient group is now required.
引用
收藏
页码:735 / 751
页数:17
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