New unnatural L-nucleoside enantiomers: From their stereospecific synthesis to their biological activities

被引：16

作者：

Gosselin, G

Boudou, V

Griffon, JF

Pavia, G

Pierra, C

Imbach, JL

Aubertin, AM

Schinazi, RF

Faraj, A

Sommadossi, JP

机构：

[1] UNIV STRASBOURG 1,INSERM,U 74,F-67000 STRASBOURG,FRANCE

[2] EMORY UNIV,SCH MED,VET AFFAIRS MED CTR,DECATUR,GA 30033

[3] UNIV ALABAMA,DEPT PHARMACOL,BIRMINGHAM,AL 35294

来源：

NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 7-9期

关键词：

D O I：

10.1080/07328319708006190

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several purine and pyrimidine beta-L-dideoxynucleosides were stereospecifically synthesized and their antiviral properties examined. Two of them, namely beta-L-2', 3'-dideoxyadenosine (beta-L-ddA) and its 2',3'-didehydro derivative (beta-L-d4A) were found to have significant anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activities in cell culture.

引用

页码：1389 / 1398

页数：10

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