Identification and characterization of an aadB gene cassette at a secondary site in a plasmid from Acinetobacter

被引：19

作者：

Segal, H

Elisha, BG

机构：

[1] UNIV CAPE TOWN, SCH MED, DEPT MED MICROBIOL, ZA-7925 CAPE TOWN, SOUTH AFRICA

[2] GROOTE SCHUUR HOSP, ZA-7925 CAPE TOWN, SOUTH AFRICA

来源：

FEMS MICROBIOLOGY LETTERS | 1997年 / 153卷 / 02期

基金：

英国医学研究理事会;

关键词：

Acinetobacter; gene cassette; integron;

D O I：

10.1016/S0378-1097(97)00268-1

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Transformation studies showed that an aminoglycoside resistance gene, aadB, is carried on a 6.0-kb plasmid (pRAY) in a clinical isolate of Acinetobacter (strain SUN). The gene was cloned and sequenced. An analysis of the DNA sequencing data showed that although the aadB gene is part of cassette, it is not associated with an integron. Rather, the aadB cassette has recombined at a secondary site downstream of putative promoters on pRAY.

引用

页码：321 / 326

页数：6

共 20 条

[1]

BARRY A L, 1976, ANTIMICROBIC SUSCEPT, P92

[2] Acinetobacter spp, as nosocomial pathogens: Microbiological, clinical, and epidemiological features [J].