Therapeutic Potential of Targeting Wnt/-Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress

被引：162

作者：

Bahrami, Afsane ^{[1
]}

Amerizadeh, Forouzan ^{[1
]}

ShahidSales, Soodabeh ^{[4
]}

Khazaei, Majid ^{[5
]}

Ghayour-Mobarhan, Majid ^{[4
]}

Sadeghnia, Hamid Reza ^{[1
]}

Maftouh, Mina ^{[3
]}

Hassanian, Seyed Mahdi ^{[2
,3
]}

Avan, Amir ^{[3
,4
]}

机构：

[1] Mashhad Univ Med Sci, Fac Med, Dept Modern Sci & Technol, Mashhad, Iran

[2] Mashhad Univ Med Sci, Sch Med, Dept Med Biochem, Mashhad, Iran

[3] Mashhad Univ Med Sci, Sch Med, Metab Syndrome Res Ctr, Mashhad, Iran

[4] Mashhad Univ Med Sci, Sch Med, Canc Res Ctr, Mashhad, Iran

[5] Mashhad Univ Med Sci, Neurogen Inflammatory Res Ctr, Dept Physiol, Mashhad, Iran

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2017年 / 118卷 / 08期

关键词：

COLON CANCER; Wnt; -CATENIN; INHIBITOR; THERAPEUTIC TARGET; SMALL-MOLECULE INHIBITOR; BETA-CATENIN; COLON-CANCER; STEM-CELLS; SIGNALING PATHWAY; PDZ DOMAIN; E-CADHERIN; ACTIVATION; EXPRESSION; DIFFERENTIATION;

D O I：

10.1002/jcb.25903

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Wnt/-catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. Aberrant activation of this pathway is associated with cell proliferation, invasive behaviors, and cell resistance, suggesting its potential value as a therapeutic target in treatment of CRC. Several agents have been developed for targeting of this pathway (e.g, natural agents: curcumin, 3,3-diindolylmethane, phytoestrogen; Synthetic/small Wnt inhibitors: Rofecoxib; PRI-724, CWP232291; and monoclonal antibody against frizzled receptors, Vanituctumab). This review summarizes the current knowledge about the therapeutic potential of targeting Wnt pathway with particular emphasis on preclinical/clinical studies in treatment of colorectal cancer. J. Cell. Biochem. 118: 1979-1983, 2017. (c) 2017 Wiley Periodicals, Inc.

引用

页码：1979 / 1983

页数：5

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