Cytonic acids A and B:: Novel tridepside inhibitors of hCMV protease from the endophytic fungus Cytonaema species

被引：63

作者：

Guo, BY ^{[1
]}

Dai, JR ^{[1
]}

Ng, S ^{[1
]}

Huang, YC ^{[1
]}

Leong, CY ^{[1
]}

Ong, W ^{[1
]}

Carté, BK ^{[1
]}

机构：

[1] Ctr Nat Prod Res, Inst Mol & Cell Biol, Singapore 118240, Singapore

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 05期

关键词：

D O I：

10.1021/np990467r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two novel human cytomegalovirus protease inhibitors, cytonic acids A (1) and B (2), have been isolated from the solid-state fermentation of the endophytic fungi Cytonaema sp. Their structures as p-tridepside isomers were elucidated by MS and NMR methods.

引用

页码：602 / 604

页数：3

共 12 条

[1]

ALFORD CA, 1990, VIROLOGY, P1981

[2] SYNTHESIS OF ORCINOL TRIDEPSIDES AND APHTHOSIN, AN ORCINOL TETRADEPSIDE [J].

BRYAN, AJ ;

ELIX, JA ;

NORFOLK, S .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1976, 29 (05) :1079-1086

[3] 5-O-METHYLHIASCIC ACID, A NEW TRIDEPSIDE FROM AUSTRALIAN LICHENS [J].

ELIX, JA ;

JAYANTHI, VK .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1977, 30 (12) :2695-2704

[4] 2''-O-METHYLGYROPHORIC ACID, A NEW LICHEN TRIDEPSIDE [J].

ELIX, JA ;

BARBERO, M ;

GIRALT, M ;

LUMBSCH, HT ;

MCCAFFERY, LF .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1995, 48 (10) :1761-1765

[5] 4,5-DI-O-METHYLHIASCIC ACID, A NEW TRIDEPSIDE FROM LICHENS PARMELIA-PSEUDOFATISCENS AND PARMELIA-HORRESCENS [J].

ELIX, JA ;

ENGKANINAN, U .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1976, 29 (12) :2701-2705

[6] 4-O-METHYLHIASCIC ACID AND 5-O-ACETYL-4-O-METHYLHIASCIC ACID, 2 NEW LICHEN TRIDEPSIDES [J].

ELIX, JA ;

YU, J ;

TONSBERG, T .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1991, 44 (01) :157-163

[7] 3-HYDROXYUMBILICARIC ACID AND 3-METHOXYUMBILICARIC ACID, NEW TRIDEPSIDES FROM THE LICHEN PARMELINOPSIS-BONARIENSIS [J].

ELIX, JA ;

JIN, Y ;

ADLER, MT .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1989, 42 (05) :765-770

[8] 2-O-METHYLHIASCIC ACID, A NEW TRIDEPSIDE IN THE LICHEN PARMELINOPSIS-NEODAMAZIANA [J].

ELIX, JA ;

JAYANTHI, VK ;

WARDLAW, JH .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1989, 42 (08) :1423-1426

[9]

Gibson Wade, 1995, Perspectives in Drug Discovery and Design, V2, P413, DOI 10.1007/BF02172034

[10] CRUSTINIC ACID, A TRIDEPSIDE FROM UMBILICARIA-CRUSTULOSA [J].

HUNECK, S ;

PORZEL, A ;

SCHMIDT, J ;

FEIGE, GB ;

POSNER, B .

PHYTOCHEMISTRY, 1993, 32 (02) :475-477

← 1 2 →