Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy

被引：23

作者：

Clerici, M ^{[1
]}

Saresella, M

Trabattoni, D

Ferrante, P

Vanzulli, A

Vigano, A

机构：

[1] Univ Milan, Dept Immunol, I-20157 Milan, Italy

[2] Univ Milan, Dept Pediat 4, I-20157 Milan, Italy

[3] Fdn IRCCS, Dept Virol, Biol Lab, I-20148 Milan, Italy

[4] Osped Maggiore, Dept Radiol, I-20145 Milan, Italy

来源：

AIDS | 2002年 / 16卷 / 16期

关键词：

D O I：

10.1097/00002030-200211080-00015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4 T cell counts. HAART-associated immune restoration is often difficult to predict. We verified whether increases in CD4 cells, and particularly in cells of the naive phenotype, would be associated in HAART-treated children with thymic volume. Long-term immune reconstitution is significantly better in children with bigger thymuses at the initiation of HAART. Thymic volume has a strong predictive value for the immunological effect of HAART.

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页码：2219 / 2221

页数：3

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