Microstructured Surfaces Cause Severe but Non-Detrimental Deformation of the Cell Nucleus

被引：105

作者：

Davidson, Patricia M. ^{[1
]}

Ozcelik, Hayriye ^{[2
]}

Hasirci, Vasif ^{[2
]}

Reiter, Guenter ^{[3
]}

Anselme, Karine ^{[1
]}

机构：

[1] Univ Haute Alsace, CNRS, LRC 7228, Inst Sci Mat Mulhouse, F-68057 Mulhouse, France

[2] BIOMAT, Dept Biol Sci, METU, Biotechnol Res Unit, TR-06531 Ankara, Turkey

[3] Univ Freiburg, Inst Phys, D-79104 Freiburg, Germany

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 35期

关键词：

DIFFERENTIATION; PROLIFERATION; DEFORMABILITY; FIBROBLASTS; ALIGNMENT; LINES;

D O I：

10.1002/adma.200900582

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Surface features on the length scale of organelles allow their manipulation. Here, we present observations of an unexpected deformation of nuclei within cells growing on surfaces with micrometer-sized pillars. Our results demonstrate that a microstructured surface can induce strong shape deformations in cells, without harmful consequences, and strongly suggest that these are limited to cancerous cells.

引用

页码：3586 / +

页数：6

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