Expression of NADPH oxidase-dependent resistance to listeriosis in mice occurs during the first 6 to 12 hours of liver infection

被引：9

作者：

LaCourse, R ^{[1
]}

Ryan, L ^{[1
]}

North, RJ ^{[1
]}

机构：

[1] Trudeau Inst, Saranac Lake, NY 12983 USA

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 12期

关键词：

D O I：

10.1128/IAI.70.12.7179-7181.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Wild-type mice inoculated with Listeria monocytogenes intravenously were capable of reducing the bacterial load in their livers by 90% within 6 h. In contrast, mice with deletions of the gene for NADPH oxidase were incapable of expressing this early oxygen-dependent anti-Listeria defense and consequently showed higher levels of liver infection at later times.

引用

收藏

页码：7179 / 7181

页数：3

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