Dietary components impact histone modifications and cancer risk

被引:22
作者
Davis, Cindy D. [1 ]
Ross, Sharon A. [1 ]
机构
[1] NCI, Nutr Sci Res Grp, Div Canc Prevent, Rockville, MD 20892 USA
关键词
cancer prevention; diet; epigenetics; histones;
D O I
10.1301/nr.2007.feb.88-94
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Epigenetics refers to the study of heritable changes in gene expression that occur without a change in the DNA sequence and constitute an important mechanism by which dietary components can selectively activate or inactivate gene expression. Alterations in histone acetylation and methylation are a common hallmark of human cancer. This review focuses on several histone-modifying enzymes that are associated with cancer development and their modification by bioactive food components.
引用
收藏
页码:88 / 94
页数:7
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