Induction of immunological tolerance using monoclonal antibodies: Applications to organ transplantation and autoimmune disease

被引：7

作者：

Bach, JF ^{[1
]}

机构：

[1] Hop Necker Enfants Malad, INSERM, U580, F-75015 Paris, France

来源：

COMPTES RENDUS BIOLOGIES | 2006年 / 329卷 / 04期

关键词：

monoclonal antibodies; tolerance; insulin-dependent diabetes mellitus; organ transplantation; anti-CD3;

D O I：

10.1016/j.crvi.2005.12.007

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immunologic tolerance is a state of immune paralysis specific to a given antigen (the tolerogen) coexisting with the maintenance of normal immunocompetence towards other antigens. Anti-T cell monoclonal antibodies allow its induction in organ transplantation and autoimmune disease essentially through the stimulation of regulatory T cells. Very promising results obtained in animals have been recently confirmed in the human in recent-onset insulin-dependent diabetes mellitus with an anti-CD3 antibody (with long-term remission of the disease following a treatment of only six days).

引用

页码：260 / 262

页数：3

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