Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

被引：415

作者：

Chapman, HA ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

CURRENT OPINION IN CELL BIOLOGY | 1997年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(97)80126-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular migration is critically dependent on an interplay between forces of attachment and detachment. Recent studies show that the serine protease urokinase and its major inhibitor and receptor regulate the adhesive properties of integrins, at least in part through initiation of cellular signals. These new functions for an old protease system imply intricate connections between proteolysis and adhesion that operate at the cell surface to regulate migration.

引用

收藏

页码：714 / 724

页数：11

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