alpha(1)-acid glycoprotein reduces local and remote injuries after intestinal ischemia in the rat

被引:68
作者
Williams, JP
Weiser, MR
Pechet, TTV
Kobzik, L
Moore, FD
Hechtman, HB
机构
[1] BRIGHAM & WOMENS HOSP, DEPT SURG, BOSTON, MA 02115 USA
[2] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 1997年 / 273卷 / 05期
关键词
complement; lung; neutrophils; selectins; sialyl Lewis(x);
D O I
10.1152/ajpgi.1997.273.5.G1031
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The aim of this study was to look at the role of alpha(1)-acid glycoprotein as a natural anti-inflammatory agent with particular respect to its antineutrophil and anticomplement activity. A recombinantly engineered form of sialyl Lewis(x) (sLe(x))-bearing alpha(1)-acid glycoprotein (sAGP) was administered intravenously to pentobarbital-anesthetized rats after 50 min of intestinal ischemia just before 4 h of reperfusion. A non-sLe(x)-bearing form of AGP (nsAGP) was used as control. sAGP-treated animals had a 62% reduction (P < 0.05) in remote lung injury, assessed by I-125-albumin permeability, compared with those treated with nsAGP (permeability index of 3.61 +/- 0.15 x 10(-3) and 5.18 +/- 0.67 x 10(-3), respectively). There was a reduction in pulmonary myeloperoxidase levels in sAGP-treated rats compared with nsAGP-treated rats. Complement-dependent intestinal injury, assessed by I-125-albumin permeability was reduced by 28% (P < 0.05) in animals treated with sAGP (7.58 +/- 0.63) compared with those treated with nsAGP (10.4 +/- 0.54). We conclude that sAGP ameliorates both complement-and neutrophil-mediated injuries.
引用
收藏
页码:G1031 / G1035
页数:5
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