Interaction of Co, Mn, Mg and Al with d(GCGTACGC): A spectroscopic study

被引：9

作者：

Rajan, MT

Kumar, DCCS

Vishnuvardhan, D

Rao, KSJ

Viswamitra, MA

机构：

[1] INDIAN INST SCI, DEPT PHYS, BANGALORE 560012, KARNATAKA, INDIA

[2] INDIAN INST SCI, JAWAHARLAL NEHRU CTR ADV SCI RES, BANGALORE 560012, KARNATAKA, INDIA

[3] CENT FOOD TECHNOL RES INST, DEPT BIOCHEM & NUTR, MYSORE 570013, KARNATAKA, INDIA

来源：

MOLECULAR BIOLOGY REPORTS | 1996年 / 22卷 / 01期

关键词：

DNA; interaction; spectroscopy and trace elements;

D O I：

10.1007/BF00996304

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spectroscopic study on the interactions of trace elements Co, Mn, Mg and Al with d(GCGTACGC) indicated the following: Al and Mg did not alter T-m values. Mn enhanced T-m at lower concentration and decreased it at higher concentrations. Interestingly Co at higher concentration elevated the T-m. These studies also showed lower concentrations of Mn displaced EtBr, whereas Al could displace it at higher ionic strength. Mg and Co displaced EtBr fluorescence at moderate concentrations. The binding constant values and CD spectra clearly indicated strong binding of these elements to DNA.

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收藏

页码：47 / 52

页数：6

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