Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

被引：35

作者：

Cayir, Kerim ^{[2
]}

Karadeniz, Ali ^{[1
]}

Yildirim, Abdulkadir ^{[3
]}

Kalkan, Yildiray ^{[4
]}

Karakoc, Akar ^{[3
]}

Keles, Mustafa ^{[2
]}

Tekin, Salim Basol ^{[2
]}

机构：

[1] Ataturk Univ, Dept Physiol, Fac Vet Med, TR-25700 Erzurum, Turkey

[2] Ataturk Univ, Dept Internal Med, Fac Med, TR-25700 Erzurum, Turkey

[3] Ataturk Univ, Dept Biochem, Fac Med, TR-25700 Erzurum, Turkey

[4] Ataturk Univ, Dept Histol & Embryol, Fac Med, TR-25700 Erzurum, Turkey

来源：

CENTRAL EUROPEAN JOURNAL OF MEDICINE | 2009年 / 4卷 / 02期

关键词：

L-carnitine; Cisplatin; Liver; Kidney; Oxidative damage; PROPIONYL-L-CARNITINE; ACUTE-RENAL-FAILURE; INDUCED OXIDATIVE DAMAGE; INDUCED HEPATOTOXICITY; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; ELLAGIC ACID; VITAMIN-E; GLUTATHIONE; TISSUES;

D O I：

10.2478/s11536-009-0021-x

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The present study was designed to investigate the protective effects of L-carnitine (LC) on changes in the levels of lipid peroxidation and endogenous antioxidants induced by cisplatin (cis-diamminedichloroplatinum II, CDDP) in the liver and kidney tissues of rats. Twenty-four Sprague Dawley rats were equally divided into four groups of six rats each: control, cisplatin, L-carnitine, and L-carnitine plus cisplatin. The degree of protection produced by L-carnitine was evaluated by determining the level of malondialdehyde (MDA). The activity of glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), and superoxide dismutase (SOD) were estimated from liver and kidney homogenates, and the liver and kidney were histologically examined as well. L-carnitine elicited significant liver and kidney protective activity by decreasing the level of lipid peroxidation (MDA) and elevating the activity of GSH, GSHPx, GST, and SOD. Furthermore, these biochemical observations were supported by histological findings. In conclusion, the present study indicates a significant role for reactive oxygen species (ROS) and their relation to liver and kidney dysfunction, and points to the therapeutic potential of LC in CDDP-induced liver and kidney toxicity.

引用

页码：184 / 191

页数：8

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