Interleukin-18 and the treatment of rheumatoid arthritis

被引：33

作者：

Dinarello, CA ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Div Infect Dis, Dept Med, Denver, CO 80262 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2004年 / 30卷 / 02期

关键词：

D O I：

10.1016/j.rdc.2004.02.001

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Interleukin (IL)-18 is a new member of the IL-1 family of proinflammatory cytokines. Based on preclinical studies in animals, IL-18 likely plays a role in rheumatoid arthritis, and strategies to block IL-18 activity are underway in clinical trials. In one of these trials, a naturally occurring IL-18 binding protein (IL-18BP) binds IL-18 with a high affinity and reduces disease severity in models of inflammatory diseases. IL-18BP is not the soluble receptor for IL-18 but rather a distinct molecule, which appears. to be distantly related to the IL-1 receptor type II, both structurally and functionally, and hence represents part of the IL-1 family of receptors.

引用

页码：417 / +

页数：19

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