Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease

被引：52

作者：

Zabetian, C. P.

Morino, H.

Ujike, H.

Yamamoto, M.

Oda, M.

Maruyama, H.

Izumi, Y.

Kaji, R.

Griffith, A.

Leis, B. C.

Roberts, J. W.

Yearout, D.

Samii, A.

Kawakami, H.

机构：

[1] Ctr Geriatr Res Educ & Clin, VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA

[2] Univ Washington, Sch Med, Dept Neurol, Seattle, WA 98195 USA

[3] VA Puget Sound Hlth Care Syst, NW Parkinsons Dis Res Educ & Clin Ctr, Seattle, WA USA

[4] Hiroshima Univ, Grad Sch Biomed Sci, Res Inst Radiat Biol & Med, Dept Epidemiol, Hiroshima 730, Japan

[5] Hiroshima Univ, Grad Sch Biomed Sci, Dept Clin Neurosci & Therapeut, Hiroshima 730, Japan

[6] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat, Okayama 7008530, Japan

[7] Kagawa Prefectural Cent Hosp, Dept Neurol, Takamatsu, Kagawa, Japan

[8] Sumimoto Hosp, Dept Neurol, Osaka, Japan

[9] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Clin Neurosci, Tokushima 770, Japan

[10] Evergreen Hosp, Med Ctr, Booth Gardner Parkinsons Care Ctr, Kirkland, WA USA

[11] Virginia Mason Med Ctr, Seattle, WA 98101 USA

来源：

NEUROLOGY | 2006年 / 67卷 / 04期

关键词：

D O I：

10.1212/01.wnl.0000227732.37801.d4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

LRRK2 G2019S is the most common known cause of Parkinson disease (PD) in patients of European origin, but little is known about its distribution in other populations. The authors identified two of 586 Japanese patients with PD heterozygous for the mutation who shared a haplotype distinct from that observed in Europeans. This suggests that G2019S originated from separate founders in Europe and Japan and is more widely dispersed than previously recognized.

引用

页码：697 / 699

页数：3

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