Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833

被引：172

作者：

vanAsperen, J

vanTellingen, O

Sparreboom, A

Schinkel, AH

Borst, P

Nooijen, WJ

Beijnen, JH

机构：

[1] NETHERLANDS CANC INST,DEPT MOL BIOL,NL-1066 CX AMSTERDAM,NETHERLANDS

[2] SLOTERVAART HOSP,DEPT PHARM,NL-1066 EC AMSTERDAM,NETHERLANDS

来源：

BRITISH JOURNAL OF CANCER | 1997年 / 76卷 / 09期

关键词：

paclitaxel (Taxol); SDZ PSC 833; oral bioavailability; P-glycoprotein; reversal agent;

D O I：

10.1038/bjc.1997.530

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein substrate drugs. We show here a 10-fold increased oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. These results encourage further research on the development of a clinically useful oral formulation of paclitaxel.

引用

页码：1181 / 1183

页数：3

共 18 条

[1]

BOESCH D, 1991, CANCER RES, V51, P4226

[2] THE 3 MOUSE MULTIDRUG RESISTANCE (MDR) GENES ARE EXPRESSED IN A TISSUE-SPECIFIC MANNER IN NORMAL MOUSE-TISSUES [J].