Foxp3: a critical regulator of the development and function of regulatory T cells

被引：226

作者：

Hori, S

Sakaguchi, S

机构：

[1] RIKEN, Res Ctr Allergy & Immunol, Res Unit Immune Homeostasis, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[2] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan

[3] Kyoto Univ, Int Frotier Med Sci, Kyoto 6068507, Japan

[4] Japan Sci & Technol Agcy, CRESTO, Kawaguchi, Saitama 3320012, Japan

[5] RIKEN, Res Ctr Allergy & Immunol, Res Unit Immunopathol, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 08期

关键词：

immunological tolerance; autoimmunity; immune regulation; regulatory T cells; Foxp3;

D O I：

10.1016/j.micinf.2004.02.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells are capable of suppressing deleterious immune responses against self- or non-self-antigens. Their essential role in tolerance and immune regulation has been illustrated by recent findings that mutations in the Foxp3 gene leads to the defective development of regulatory T cells and the emergence of a fatal autoimmune, inflammatory and allergic disease. This review discusses the critical role for this transcription factor in the development and function of regulatory T cells. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：745 / 751

页数：7

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