Biodegradable Thermoresponsive Microparticle Dispersions for Injectable Cell Delivery Prepared Using a Single-Step Process

被引：52

作者：

Wang, Wenxin ^{[2
]}

Liang, He ^{[2
]}

Al Ghanami, Racha Cheikh ^{[2
]}

Hamilton, Lloyd ^{[2
]}

Fraylich, Michael ^{[1
]}

Shakesheff, Kevin M. ^{[2
]}

Saunders, Brian ^{[1
]}

Alexander, Cameron ^{[2
]}

机构：

[1] Univ Manchester, Sch Mat, Manchester Mat Sci Ctr, Biomat Res Grp, Manchester M1 7HS, Lancs, England

[2] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 18期

基金：

英国工程与自然科学研究理事会;

关键词：

TRANSFER RADICAL POLYMERIZATION; CROSS-LINKED MICELLES; AQUEOUS-SOLUTIONS; REGENERATIVE MEDICINE; CULTURE SURFACES; TEMPERATURE; COPOLYMERS; POLYMERS; BLOCK; ACID);

D O I：

10.1002/adma.200800382

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Surface-engineered microparticles; with a biodegradable polymer core and a programmable thermoresponsive biocompatible copolymer corona are produced. The particles form free-flowing dispersions below 37 degrees C, but form porous space-filling gels above this temperature, as a result of chain collapse of the copolymer corona. When particles are mixed with biological materials, they form encapsulating gels that can support cell growth.

引用

页码：1809 / +

页数：6

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