学术探索
学术期刊
新闻热点
数据分析
智能评审

Proteolysis and the cell cycle: with this RING I do thee destroy

被引：257
作者：
Tyers, M
Jorgensen, P
机构：
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Program Mol Biol & Canc, Toronto, ON M5G 1X5, Canada
[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 01期
基金：
英国医学研究理事会; 加拿大自然科学与工程研究理事会;
关键词：
D O I：
10.1016/S0959-437X(99)00049-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The ubiquitin system drives the cell division cycle by the timely destruction of numerous regulatory proteins. Remarkably, the two main activities that catalyze substrate ubiquitination in the cell cycle, the Skp1-Cdc53/cullin-F-box protein (SCF) complexes and the anaphase-promoting complex/cyclosome (APC/C), define a new superfamily of E3 ubiquitin ligases, all based on related cullin and RING-H2 finger protein subunits. The circuits that interconnect the SCF, APC/C and cyclin-dependent kinase activities form a master oscillator that coordinates the replication and segregation of the genome.
引用
收藏
页码：54 / 64
页数：11
相关论文
共 88 条
  • [1] Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage
    Alexandru, G
    Zachariae, W
    Schleiffer, A
    Nasmyth, K
    [J]. EMBO JOURNAL, 1999, 18 (10) : 2707 - 2721
  • [2] Chromosome separation and exit from mitosis in budding yeast: Dependence on growth revealed by cAMP-mediated inhibition
    Anghileri, P
    Branduardi, P
    Sternieri, F
    Monti, P
    Visintin, R
    Bevilacqua, A
    Alberghina, L
    Martegani, E
    Baroni, MD
    [J]. EXPERIMENTAL CELL RESEARCH, 1999, 250 (02) : 510 - 523
  • [3] Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast
    Barral, Y
    Parra, M
    Bidlingmaier, S
    Snyder, M
    [J]. GENES & DEVELOPMENT, 1999, 13 (02) : 176 - 187
  • [4] Cell cycle-regulated proteolysis of mitotic target proteins
    Bastians, H
    Topper, LM
    Gorbsky, GL
    Ruderman, JV
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (11) : 3927 - 3941
  • [5] SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
    Carrano, AC
    Eytan, E
    Hershko, A
    Pagano, M
    [J]. NATURE CELL BIOLOGY, 1999, 1 (04) : 193 - 199
  • [6] Identification of a family of human F-box proteins
    Cenciarelli, C
    Chiaur, DS
    Guardavaccaro, D
    Parks, W
    Vidal, M
    Pagano, M
    [J]. CURRENT BIOLOGY, 1999, 9 (20) : 1177 - 1179
  • [7] The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae
    Charles, JF
    Jespersen, SL
    Tinker-Kulberg, RL
    Hwang, L
    Szidon, A
    Morgan, DO
    [J]. CURRENT BIOLOGY, 1998, 8 (09) : 497 - 507
  • [8] An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast
    Ciosk, R
    Zachariae, W
    Michaelis, C
    Shevchenko, A
    Mann, M
    Nasmyth, K
    [J]. CELL, 1998, 93 (06) : 1067 - 1076
  • [9] Pds1p of budding yeast has dual roles: inhibition of anaphase initiation and regulation of mitotic exit
    Cohen-Fix, O
    Koshland, D
    [J]. GENES & DEVELOPMENT, 1999, 13 (15) : 1950 - 1959
  • [10] Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E
    Dealy, MJ
    Nguyen, KVT
    Lo, J
    Gstaiger, M
    Krek, W
    Elson, D
    Arbeit, J
    Kipreos, ET
    Johnson, RS
    [J]. NATURE GENETICS, 1999, 23 (02) : 245 - 248
123456789