The structure and function of G-protein-coupled receptors

被引：1752

作者：

Rosenbaum, Daniel M. ^{[1
]}

Rasmussen, Soren G. F. ^{[1
]}

Kobilka, Brian K. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Cellular & Mol Physiol, Palo Alto, CA 94305 USA

来源：

NATURE | 2009年 / 459卷 / 7245期

关键词：

BETA-ADRENERGIC-RECEPTOR; INTERNAL WATER-MOLECULES; CONSERVED ASPARTIC-ACID; CRYSTAL-STRUCTURE; BETA(2)-ADRENERGIC RECEPTOR; BOVINE RHODOPSIN; DRUG DISCOVERY; HELIX MOVEMENT; BINDING-SITE; IONIC LOCK;

D O I：

10.1038/nature08144

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.

引用

页码：356 / 363

页数：8

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