The anthracycline antitumor agents doxorubicin and daunorubicin reduce the activity of Candida albicans phospholipase B

被引：5

作者：

Arai, R

Sugita, T

Nishikawa, A

机构：

[1] Meiji Pharmaceut Univ, Dept Microbiol, Tokyo 2048588, Japan

[2] Meiji Pharmaceut Univ, Dept Immunobiol, Tokyo 2048588, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2004年 / 48卷 / 09期

关键词：

Candida albicans; doxorubicin; daunorubicin; phospholipase B;

D O I：

10.1111/j.1348-0421.2004.tb03477.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

A pathogenic yeast, Candida albicans, causes life-threatening infection in immunocompromised patients. Inhibiting the production or release of phospholipase B by C albicans should reduce direct host cell damage, and inhibit the release of eicosanoids from cells of this microorganism. Of the antitumor agents tested, doxorubicin and daunorubicin inhibited the activity of phospholipase B, and prostaglandin production by C albicans. These two agents have the potential to inhibit the activity of C albicans phospholipase B, although the inhibitory concentrations exceeded the clinical dose.

引用

收藏

页码：665 / 667

页数：3

相关论文

共 24 条

[1]

BETZ M, 1991, J IMMUNOL, V146, P108

[2]

Effect of ritonavir and saquinavir on Candida albicans growth rate and in vitro activity of aspartyl proteinases [J].

Blanco, MT ;

Hurtado, C ;

Pérez-Giraldo, C ;

Morán, FJ ;

González-Velasco, C ;

Gómez-García, AC .

MEDICAL MYCOLOGY, 2003, 41 (02) :167-170

[3]

HIV-protease inhibitors reduce cell adherence of Candida albicans strains by inhibition of yeast secreted aspartic proteases [J].

Borg-von Zepelin, M ;

Meyer, I ;

Thomssen, R ;

Würzner, R ;

Sanglard, D ;

Telenti, A ;

Monod, M .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1999, 113 (05) :747-751

[4]

Candida albicans:: adherence, signaling and virulence [J].

Calderone, R ;

Suzuki, S ;

Cannon, R ;

Cho, T ;

Boyd, D ;

Calera, J ;

Chibana, H ;

Herman, D ;

Holmes, A ;

Jeng, HW ;

Kaminishi, H ;

Matsumoto, T ;

Mikami, T ;

O'Sullivan, JM ;

Sudoh, M ;

Suzuki, M ;

Nakashima, Y ;

Tanaka, T ;

Tompkins, GR ;

Watanabe, T .

MEDICAL MYCOLOGY, 2000, 38 :125-137

[5]

De Bernardis F, 2001, MED MYCOL, V39, P303, DOI 10.1080/mmy.39.4.303.313

[6]

MODULATION OF CELL SURFACE-ASSOCIATED MANNOPROTEIN ANTIGEN EXPRESSION IN EXPERIMENTAL CANDIDAL VAGINITIS [J].

DEBERNARDIS, F ;

MOLINARI, A ;

BOCCANERA, M ;

STRINGARO, A ;

ROBERT, R ;

SENET, JM ;

ARANCIA, G ;

CASSONE, A .

INFECTION AND IMMUNITY, 1994, 62 (02) :509-519

[7]

Potential role of phospholipases in virulence and fungal pathogenesis [J].

Ghannoum, MA .

CLINICAL MICROBIOLOGY REVIEWS, 2000, 13 (01) :122-+

[8]

Prostaglandin E2 inhibits production of the inflammatory chemokines CCL3 and CCL4 in dendritic cells [J].

Jing, H ;

Vassiliou, E ;

Ganea, D .

JOURNAL OF LEUKOCYTE BIOLOGY, 2003, 74 (05) :868-879

[9]

Kalinski P, 1997, J IMMUNOL, V159, P28

[10]

Effects of the human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV-Infected patients [J].

Korting, HC ;

Schaller, M ;

Eder, G ;

Hamm, G ;

Böhmer, U ;

Hube, B .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (08) :2038-2042