The crystal structure of human cyclin H

被引：31

作者：

Andersen, G ^{[1
]}

Poterszman, A ^{[1
]}

Egly, JM ^{[1
]}

Moras, D ^{[1
]}

Thierry, JC ^{[1
]}

机构：

[1] UNIV STRASBOURG 1, INSERM, CNRS, INST GENET & BIOL MOL & CELLULAIRE, F-67404 ILLKIRCH GRAFFENSTADEN, FRANCE

来源：

FEBS LETTERS | 1996年 / 397卷 / 01期

关键词：

human; cyclin; cell cycle; TFIIH; transcription factor; X-ray structure;

D O I：

10.1016/S0014-5793(96)01143-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of human cyclin H has been solved at 2.6 Angstrom resolution by the MIR method and refined to an R-factor of 23.1%. The core of the molecule consists of two helical repeats adopting the canonical cyclin fold already observed in the structures of cyclin A [Brown et al. (1995) Structure 3, 1235-1247; Jeffrey et al. (1995) Nature 376, 313-320; Russo et al. (1996) Nature 382, 325-331] and TFIIB [Nikoilov et al. (1995) Nature 377, 119-128]. The N-terminal and C-terminal residues form a new domain built on two long helices interacting essentially with the first repeat of the molecule.

引用

页码：65 / 69

页数：5

共 33 条

[1] MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH [J].