Immunologic properties of Epstein-Barr virus-seronegative adults

被引：11

作者：

Jabs, WJ ^{[1
]}

Wagner, HJ ^{[1
]}

Neustock, P ^{[1
]}

Kluter, H ^{[1
]}

Kirchner, H ^{[1
]}

机构：

[1] UNIV LUBECK,SCH MED,DEPT PEDIAT,D-23538 LUBECK,GERMANY

来源：

JOURNAL OF INFECTIOUS DISEASES | 1996年 / 173卷 / 05期

关键词：

D O I：

10.1093/infdis/173.5.1248

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epstein-Barr virus (EBV) seronegativity is rare in people > 20 years old. However, some persons remain EBV-seronegative for nearly their whole lives. The aim of this study was to examine properties of the immune system of EBV-seronegative adults that could contribute to long-term EBV seronegativity. Therefore, differential blood cell counts and lymphocyte subpopulations were determined, and the production of interferon (IFN)-alpha and -gamma and interleukin (IL)-6 and -2 in a whole blood assay was investigated. Whereas no differences in the distribution of lymphocyte subpopulations between EBV-seronegative and -positive adults were found, a significant higher percentage of monocytes in EBV-seronegative adults was observed. Significantly more IFN-alpha and IL-6 were detected in culture supernatants of EBV-seronegative persons after stimulation with Newcastle disease virus. In contrast, no differences in the induction of the lymphokines IFN-gamma and IL-2 were seen. These data suggest that faster and higher production of IFN-alpha and IL-6 may protect EBV-seronegative adults against EBV infection.

引用

页码：1248 / 1251

页数：4

共 15 条

[1] INHIBITION OF EPSTEIN-BARR VIRUS-MEDIATED CAPPING OF CD21 CR-2 BY ALPHA-INTERFERON (IFN-ALPHA) - IMMEDIATE ANTIVIRAL ACTIVITY OF IFN-ALPHA DURING THE EARLY PHASE OF INFECTION [J].