Deregulation of protein synthesis as a mechanism of neoplastic transformation

被引:41
作者
Rosenwald, IB
机构
[1] Harvard-Massachusetts Inst. Technol., Division of Health Sciences, MIT, Cambridge, MA 02139
关键词
D O I
10.1002/bies.950180312
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Early research on the cell cycle revealed correlations between protein accumulation and cell proliferation. In this review, I describe the data showing that abnormality of cell growth and tumor development are dependent upon oncogene-induced increases in the levels and activity of factors that determine the rate of protein synthesis. It is proposed that the establishment of a vicious circle, namely oncoproteins --> increase in translation --> oncoproteins, is a major biological mechanism that fuels neoplastic growth. The constitutively high rates of protein synthesis and accumulation of proteins, including those necessary for DNA replication and mitosis, would drive cells to excessive proliferation.
引用
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页码:243 / 250
页数:8
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