Effects of long-term administration of enalapril on clinical indicators of renal function in dogs with compensated mitral regurgitation

被引:34
作者
Atkins, CE
Brown, WA
Coats, JR
Crawford, MA
DeFrancesco, TC
Edwards, J
Fox, PR
Keene, BW
Lehmkuhl, L
Luethy, M
Meurs, K
Petrie, JP
Pipers, F
Rosenthal, S
Sidley, JA
Straus, J
机构
[1] N Carolina State Univ, Coll Vet Med, Dept Clin Sci, Raleigh, NC 27606 USA
[2] Vet Cardiol Consults, Birmingham, MI 48009 USA
[3] Oradell Anim Hosp, Oradell, NJ 07649 USA
[4] Albany Cty Vet Hosp, Albany, NY 12203 USA
[5] Anim Med Ctr, New York, NY 10021 USA
[6] Ohio State Univ, Coll Vet Med, Dept Vet Clin Sci, Columbus, OH 43210 USA
[7] Cardioscope Pet Referral Serv, Northbrook, IL 60062 USA
[8] Merial Inc, Duluth, GA 30096 USA
[9] Chesapeake Vet Refferal Ctr, Annapolis, MD 21401 USA
来源
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION | 2002年 / 221卷 / 05期
关键词
D O I
10.2460/javma.2002.221.654
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Objective-To determine the effect of long-term administration of enalapril on renal function in dogs with severe, compensated mitral regurgitation. Design-Randomized controlled trial. Animals-139 dogs with mitral regurgitation but without overt signs of heart failure. Procedure-Dogs were randomly assigned to be treated with enalapril (0.5 mg/kg [0.23 mg/lb], PO, q 24 h) or placebo, and serum creatinine and urea nitrogen concentrations were measured at regular intervals for up to 26 months. Results-Adequate information on renal function was obtained from 132 dogs; follow-up time ranged from 0.5 to 26 months (median, 12 months). Mean serum creatinine and urea nitrogen concentrations were not significantly different between dogs receiving enalapril and dogs receiving the placebo at any time, nor were concentrations significantly different from baseline concentrations. Proportions of dogs that developed azotemia or that had a double dagger35% increase in serum creatinine or urea nitrogen concentration were also not significantly different between groups. Conclusions and Clinical Relevance-Results suggest that administration of enalapril for up to 2 years did not have any demonstrable adverse effects on renal function in dogs with severe, compensated mitral regurgitation.
引用
收藏
页码:654 / 658
页数:5
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