Cytotoxic triterpenes from a marine sponge, Stelletta sp

被引：55

作者：

McCormick, JL

McKee, TC

Cardellina, JH

Leid, M

Boyd, MR

机构：

[1] NCI,LAB DRUG DISCOVERY RES & DEV,DEV THERAPEUT PROGRAM,DIV CANC TREATMENT DIAG & CTR,FREDERICK,MD 21702

[2] OREGON STATE UNIV,COLL PHARM,CORVALLIS,OR 97331

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 11期

关键词：

D O I：

10.1021/np960541v

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of an extract of a marine sponge, Stelletta sp., has led to the isolation and characterization of four new cytotoxic isomalabaricane triterpenes, named stellettins C (1), D (2), E (3), and F (4). Three known triterpenes (5-7) were also isolated from the same extract. The most sensitive of the tested cell Lines (e.g., leukemia, central nervous system, renal) generally responded with GI(50) concentrations in the low-to-mid nanomolar range.

引用

收藏

页码：1047 / 1050

页数：4

相关论文

共 15 条

[1]

Boyd M. R., 1993, CURRENT THERAPY ONCO, P11

[2]

Boyd M. R., 1989, CANCER PRINCIPLES PR, V3, P1

[3] SOME PRACTICAL CONSIDERATIONS AND APPLICATIONS OF THE NATIONAL-CANCER-INSTITUTE IN-VITRO ANTICANCER DRUG DISCOVERY SCREEN [J].

BOYD, MR ;

PAULI, KD .

DRUG DEVELOPMENT RESEARCH, 1995, 34 (02) :91-109

[4] CYCLOSTELLETTAMINES-A-F, PYRIDINE ALKALOIDS WHICH INHIBIT BINDING OF METHYL QUINUCLIDINYL BENZILATE (QNB) TO MUSCARINIC ACETYLCHOLINE-RECEPTORS, FROM THE MARINE SPONGE, STELLETTA-MAXIMA [J].

FUSETANI, N ;

ASAI, N ;

MATSUNAGA, S ;

HONDA, K ;

YASUMURO, K .

TETRAHEDRON LETTERS, 1994, 35 (23) :3967-3970

[5] ON THE 1ST MARINE STIGMASTANE STEROLS AND STEROLS HAVING A 24,25-DOUBLE BOND - ISOLATION FROM THE SPONGE STELLETTA SP OF DEEP CORAL SEA [J].

GUERRIERO, A ;

DEBITUS, C ;

PIETRA, F .

HELVETICA CHIMICA ACTA, 1991, 74 (03) :487-494

[6] NEW CYTO-TOXIC ACRIDINE ALKALOIDS FROM 2 DEEP-WATER MARINE SPONGES OF THE FAMILY PACHASTRELLIDAE [J].

GUNAWARDANA, GP ;

KOHMOTO, S ;

BURRES, NS .

TETRAHEDRON LETTERS, 1989, 30 (33) :4359-4362

[7] BIOACTIVE MARINE METABOLITES .32. STELLETTAMIDE-A, AN ANTIFUNGAL ALKALOID FROM A MARINE SPONGE OF THE GENUS STELLETTA [J].

HIROTA, H ;

MATSUNAGA, S ;

FUSETANI, N .

TETRAHEDRON LETTERS, 1990, 31 (29) :4163-4164

[8] Jaspiferals A-G, new cytotoxic isomalabaricane-type nortriterpenoids from Okinawan marine sponge Jaspis stellifera [J].

Kobayashi, J ;

Yuasa, K ;

Kobayashi, T ;

Sasaki, T ;

Tsuda, M .

TETRAHEDRON, 1996, 52 (16) :5745-5750

[9]

LEID M, 1994, J BIOL CHEM, V269, P14175

[10] A TRITERPENOID PIGMENT WITH THE ISOMALABARICANE SKELETON FROM THE MARINE SPONGE STELLETTA SP [J].

MCCABE, T ;

CLARDY, J ;

MINALE, L ;

PIZZA, C ;

ZOLLO, F ;

RICCIO, R .

TETRAHEDRON LETTERS, 1982, 23 (33) :3307-3310