Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones

被引：91

作者：

Mei, Kui ^{[1
]}

Jin, Mei ^{[1
]}

Zhang, Shilei ^{[1
]}

Li, Ping ^{[1
]}

Liu, Wenjing ^{[1
]}

Chen, Xiaobei ^{[1
]}

Xue, Fei ^{[1
]}

Duan, Wenhu ^{[1
,2
]}

Wang, Wei ^{[1
,3
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Sci, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[3] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 13期

基金：

美国国家科学基金会;

关键词：

ORGANOCATALYTIC MICHAEL ADDITION; C BOND FORMATION; ALPHA; BETA-UNSATURATED KETONES; 1,3-DICARBONYL COMPOUNDS; ORGANIC CATALYSTS; NITROMETHANE; ALDEHYDES; EFFICIENT; DERIVATIVES; ACTIVATION;

D O I：

10.1021/ol9010322

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly enantioselective conjugate addition of nitroalkanes to enones has been developed. The process is efficiently catalyzed by a simple chiral cyclohexanediamine-derived primary amine thiourea with a broad substrate scope.

引用

页码：2864 / 2867

页数：4

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