Evidence of bacterial biofilms in human chronic sinusitis

被引:138
作者
Cryer, J [1 ]
Schipor, I [1 ]
Perloff, JR [1 ]
Palmer, JN [1 ]
机构
[1] Univ Penn, Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Div Rhinol, Philadelphia, PA 19104 USA
来源
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 2004年 / 66卷 / 03期
关键词
bacterial biofilms; Pseudomonas aeruginosa; chronic sinusitis;
D O I
10.1159/000079994
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
The purpose of this study was to evaluate whether bacterial biofilms exist on the sinus mucosa surfaces of human subjects with recalcitrant chronic sinusitis. Scanning electron microscopy was used to evaluate patients with continued symptoms of chronic sinusitis despite prior appropriate medical and surgical management. Morphologic structures that confirm the presence of bacterial biofilms were identified on the sinus mucosa of patients infected with Pseudomonas aeruginosa, a known biofilm former. The presence of bacterial biofilms may explain the recalcitrant nature of some forms of chronic sinusitis. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码:155 / 158
页数:4
相关论文
共 6 条
[1]   Bacterial biofilms: A common cause of persistent infections [J].
Costerton, JW ;
Stewart, PS ;
Greenberg, EP .
SCIENCE, 1999, 284 (5418) :1318-1322
[2]  
Costerton W, 2003, J CLIN INVEST, V112, P1466, DOI 10.1172/JCI200320365
[3]   Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media [J].
Ehrlich, GD ;
Veeh, R ;
Wang, X ;
Costerton, JW ;
Hayes, JD ;
Hu, FZ ;
Daigle, BJ ;
Ehrlich, MD ;
Post, JC .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (13) :1710-1715
[4]  
Osguthorpe JD, 2001, AM FAM PHYSICIAN, V63, P69
[5]   Direct evidence of bacterial biofilms in otitis media [J].
Post, JC .
LARYNGOSCOPE, 2001, 111 (12) :2083-2094
[6]   Antibiotic resistance of bacteria in biofilms [J].
Stewart, PS ;
Costerton, JW .
LANCET, 2001, 358 (9276) :135-138