Idiopathic aplastic anemia: Diagnosis and classification

被引：40

作者：

Dolberg, Osnat Jarchowsky ^{[1
]}

Levy, Yair ^{[2
]}

机构：

[1] Meir Med Ctr, Hematol Unit, IL-44261 Kefar Sava, Israel

[2] Meir Med Ctr, Dept Med E, IL-44261 Kefar Sava, Israel

来源：

AUTOIMMUNITY REVIEWS | 2014年 / 13卷 / 4-5期

关键词：

Aplastic anemia; Pancytopenia; Autoimmunity; Immunosuppressive therapy; RABBIT ANTITHYMOCYTE GLOBULIN; BONE-MARROW-TRANSPLANTATION; ANTI-THYMOCYTE GLOBULIN; CYCLOSPORINE; EXPRESSION; IMMUNOSUPPRESSION; CELLS; PATHOPHYSIOLOGY; MULTICENTER; COMBINATION;

D O I：

10.1016/j.autrev.2014.01.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aplastic anemia (AA) is a disease characterized by pancytopenia and hypoplastic bone marrow caused by the decrease of hematopoietic stem cells. The pathogenesis of AA is complex and involves an abnormal hematopoietic microenvironment, hematopoietic stem cell/progenitor cell deficiencies and immunity disorders. Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive and biologic drugs, and supportive care. Herein, we will update the main issues concern AA according to our literature review. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：569 / 573

页数：5

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