The promise of synthetic biology

被引:41
作者
Pleiss, Juergen [1 ]
机构
[1] Univ Stuttgart, Inst Tech Biochem, D-70569 Stuttgart, Germany
关键词
modular design; genetic circuits; protein design; DNA synthesis;
D O I
10.1007/s00253-006-0664-3
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
DNA synthesis has become one of the technological bases of a new concept in biology: synthetic biology. The vision of synthetic biology is a systematic, hierarchical design of artificial, biology-inspired systems using robust, standardized, and well-characterized building blocks. The design concept and examples from four fields of application (genetic circuits, protein design, platform technologies, and pathway engineering) are discussed, which demonstrate the usefulness and the promises of synthetic biology. The vision of synthetic biology is to develop complex systems by simplified solutions using available material and knowledge. Synthetic biology also opens a door toward new biomaterials that do not occur in nature.
引用
收藏
页码:735 / 739
页数:5
相关论文
共 56 条
[1]  
A Svendsen, 2004, ENZYME FUNCTIONALITY
[2]   Context-dependent transcription: all politics is local [J].
Alvarez, M ;
Rhodes, SJ ;
Bidwell, JP .
GENE, 2003, 313 :43-57
[3]   Protein components for nanodevices [J].
Astier, Y ;
Bayley, H ;
Howorka, S .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2005, 9 (06) :576-584
[4]   Gene network shaping of inherent noise spectra [J].
Austin, DW ;
Allen, MS ;
McCollum, JM ;
Dar, RD ;
Wilgus, JR ;
Sayler, GS ;
Samatova, NF ;
Cox, CD ;
Simpson, ML .
NATURE, 2006, 439 (7076) :608-611
[5]   Synthetic biology for nanotechnology [J].
Ball, P .
NANOTECHNOLOGY, 2005, 16 (01) :R1-R8
[6]   Synthetic biology: Starting from scratch [J].
Ball, P .
NATURE, 2004, 431 (7009) :624-626
[7]   A synthetic multicellular system for programmed pattern formation [J].
Basu, S ;
Gerchman, Y ;
Collins, CH ;
Arnold, FH ;
Weiss, R .
NATURE, 2005, 434 (7037) :1130-1134
[8]   Understanding nucleic acids using synthetic chemistry [J].
Benner, SA .
ACCOUNTS OF CHEMICAL RESEARCH, 2004, 37 (10) :784-797
[9]   Synthetic biology [J].
Benner, SA ;
Sismour, AM .
NATURE REVIEWS GENETICS, 2005, 6 (07) :533-543
[10]   De novo design of biocatalysts [J].
Bolon, DN ;
Voigt, CA ;
Mayo, SL .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (02) :125-129