Influence of Calorie Restriction on Measures of Age-Related Cognitive Decline: Role of Increased Physical Activity

被引：66

作者：

Carter, Christy S. ^{[1
,2
,3
]}

Leeuwenburgh, Christiaan ^{[1
]}

Daniels, Michael ^{[4
,5
]}

Foster, Thomas C. ^{[3
]}

机构：

[1] Univ Florida, Dept Aging & Geriatr Res, Claude D Pepper Older Amer Independence Ctr, Coll Med,Div Biol Aging,Inst Aging, Gainesville, FL 32610 USA

[2] Geriatr Res Educ & Clin Ctr, Gainesville, FL USA

[3] Univ Florida, Dept Neurosci, McKnight Brain Inst, Coll Med, Gainesville, FL 32610 USA

[4] Univ Florida, Dept Stat, Coll Liberal Arts & Sci, Gainesville, FL 32610 USA

[5] Univ Florida, Dept Epidemiol & Biostat, Coll Liberal Arts & Sci, Gainesville, FL 32610 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2009年 / 64卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Morris water maze; Object recognition; Animal models of aging; Calorie restriction; LIFELONG DIET RESTRICTION; FAT-FREE MASS; GROWTH-HORMONE; OBJECT EXPLORATION; FOOD RESTRICTION; OLDER MEN; MEMORY; PERFORMANCE; PLASTICITY; LONGEVITY;

D O I：

10.1093/gerona/glp060

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Controversy exists as to whether lifelong 40% calorie restriction (CR) enhances, has no effect on, or disrupts cognitive function during aging. Here, we report the effects of CR versus ad-lib feeding on cognitive function in male Brown Norway x Fisher344 rats across a range of ages (8-38 months), using two tasks that are differentially sensitive to age-related cognitive decline: object recognition and Morris water maze (MWM). All ages performed equally in object recognition, whereas, as a group, CR rats were impaired. In contrast, there was an age-related impairment in the MWM that was attenuated by CR as measured by time in proximity with and latency to reach the platform. Distance to the platform, a more sensitive measure, was not affected by CR. Finally, CR resulted in an overall increase in physical activity, one of several behavioral confounders to consider in the interpretation of cognitive outcomes in both tasks.

引用

页码：850 / 859

页数：10

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