Study of sesquiterpene lactones from Milleria quinqueflora on their anti-inflammatory activity using the transcription factor NF-κB as molecular target

被引：29

作者：

Castro, V

Rüngeler, P

Murillo, R

Hernandez, E

Mora, G

Pahl, HL

Merfort, I

机构：

[1] Univ Freiburg, Inst Pharmaceut Biol, D-79104 Freiburg, Germany

[2] Univ Costa Rica, Escuela Quim, San Jose, Costa Rica

[3] CIPRONA, San Jose, Costa Rica

[4] Univ Costa Rica, Fac Farm, San Jose, Costa Rica

[5] Univ Hosp Freiburg, Dept Expt Anaesthesiol, Freiburg, Germany

来源：

PHYTOCHEMISTRY | 2000年 / 53卷 / 02期

关键词：

Milleria quinqueflora; Asteraceae; sesquiterpene lactones; anti-inflammatory activity; NF-kappa B;

D O I：

10.1016/S0031-9422(99)00510-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Central America aerial parts of the Asteraceae Milleria quinqueflora are used in traditional medicine as a remedy for skin infections. Reinvestigation of this plant afforded thirteen sesquiterpene lactones (Sls), three of them are new. All isolated Sis were studied for their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target. NF-kappa B is involved in the synthesis of inflammatory mediators, such as cytokines and chemokines. NF-kappa B DNA binding was inhibited at micromolar concentrations by all Sis. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：257 / 263

页数：7

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