STI and beyond: the prospects of boosting anti-HIV immune responses

被引：19

作者：

Allen, TM ^{[1
]}

Kelleher, AD

Zaunders, J

Walker, BD

机构：

[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Div Aids, Boston, MA 02115 USA

[3] Univ New S Wales, Natl Ctr HIV Epidemiol & Clin Res, Sydney, NSW, Australia

来源：

TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 09期

关键词：

D O I：

10.1016/S1471-4906(02)02297-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Twenty years into the HIV epidemic, highly active antiretroviral therapy (HAART) represents the only effective intervention to control HIV-1 disease progression. However, the prospect of life-long treatment with HAART is challenging given cumulative drug toxicities, difficulties with adherence to complicated regimens and the looming emergence of drug-resistant viruses. The challenges are even greater in resource-poor settings where costs and logistical problems with delivery represent formidable obstacles. Alternative approaches to long-term control of viral replication and disease progression are clearly needed.

引用

页码：456 / 460

页数：5

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