Poxviruses and apoptosis: a time to die

被引:55
作者
Everett, H
McFadden, G
机构
[1] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada
[2] Robarts Res Inst, London, ON N6G 2V4, Canada
[3] Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6G 2V4, Canada
关键词
D O I
10.1016/S1369-5274(02)00340-5
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
All known apoptosis modulators in poxviruses have been shown to function as inhibitors. The mechanistic classes of these poxvirus-encoded inhibitors are quite diverse, and indicate that a wide variety of distinct host proteins in cellular apoptotic pathways have been targeted for inhibition by individual poxviruses.
引用
收藏
页码:395 / 402
页数:8
相关论文
共 94 条
[1]   The genome of fowlpox virus [J].
Afonso, CL ;
Tulman, ER ;
Lu, Z ;
Zsak, L ;
Kutish, GF ;
Rock, DL .
JOURNAL OF VIROLOGY, 2000, 74 (08) :3815-3831
[2]   The vaccinia virus soluble interferon-γ receptor is a homodimer [J].
Alcamí, A ;
Smith, GL .
JOURNAL OF GENERAL VIROLOGY, 2002, 83 :545-549
[3]  
ALCAMI A, 1995, J VIROL, V69, P4633
[4]   The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cells from the antiviral effects of IFN [J].
Alcamí, A ;
Symons, JA ;
Smith, GL .
JOURNAL OF VIROLOGY, 2000, 74 (23) :11230-11239
[5]   Host defense, viruses and apoptosis [J].
Barber, GN .
CELL DEATH AND DIFFERENTIATION, 2001, 8 (02) :113-126
[6]   Apoptosis regulators from DNA viruses [J].
Barry, M ;
McFadden, G .
CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (04) :422-430
[7]   The myxoma virus M-T4 gene encodes a novel RDEL-containing protein that is retained within the endoplasmic reticulum and is important for the productive infection of lymphocytes [J].
Barry, M ;
Hnatiuk, S ;
Mossman, K ;
Lee, SF ;
Boshkov, L ;
McFadden, G .
VIROLOGY, 1997, 239 (02) :360-377
[8]   VACCINIA VIRUS-ENCODED EIF-2-ALPHA HOMOLOG ABROGATES THE ANTIVIRAL EFFECT OF INTERFERON [J].
BEATTIE, E ;
TARTAGLIA, J ;
PAOLETTIT, E .
VIROLOGY, 1991, 183 (01) :419-422
[9]   DISTINCT PATTERNS OF IFN SENSITIVITY OBSERVED IN CELLS INFECTED WITH VACCINIA K3L(-) AND E3L(-) MUTANT VIRUSES [J].
BEATTIE, E ;
PAOLETTI, E ;
TARTAGLIA, J .
VIROLOGY, 1995, 210 (02) :254-263
[10]   Virus targeting of the tumor necrosis factor superfamily [J].
Benedict, CA ;
Ware, CF .
VIROLOGY, 2001, 289 (01) :1-5