Non-random deletions in human foamy virus long terminal repeat during viral infection

被引：8

作者：

DeCelisKosmas, J

Coronel, A

Grigorian, I

EmanoilRavier, R

TobalyTapiero, J

机构：

[1] UPR 9051, CNRS, Hôpital Saint-Louis, Paris

[2] CNRS, Pathol. Cell.: Aspects M., Hôpital Saint-Louis, F-75010 Paris

来源：

ARCHIVES OF VIROLOGY | 1997年 / 142卷 / 06期

关键词：

D O I：

10.1007/s007050050155

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have characterized a new form of human foamy virus (HFV) non-random deleted long terminal repeat (LTR) sizing 1078-bp, deleted in its U3 region, sensitive to the viral transactivator and functional in an infectious proviral clone. Besides two known HFV LTRs of 1260-bp and 1123-bp, this LTR represents the smallest, designed S. Analysis of the LTR sequence shows the presence of short direct repeats surrounding the deletions, suggesting a mechanism generating deletion by misalignment of the growing strand during replication. Our data suggest that the deleted LTRs, preferentially associated with chronic viral infection, could be related with viral persistence.

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页码：1237 / 1246

页数：10

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