Influence of ramadan on the pharmacokinetics of a single oral dose of valproic acid administered at two different times

被引：5

作者：

Aadil, N

Fassi-Fihri, A

Houti, I

Benaji, B

Ouhakki, M

Kotbi, S

Diquet, B

Hakkou, F

机构：

[1] Fac Med & Pharm, Hassan II Fdn Sci & Med Res Ramadan, Casablanca, Morocco

[2] Hop La Pitie Salpetriere, Dept Pharmacol, Lab Pharmacokinet, Paris, France

来源：

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 2000年 / 22卷 / 02期

关键词：

valproic acid; pharmacokinetics; ramadan; intake time;

D O I：

10.1358/mf.2000.22.2.796073

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study was carried out in healthy volunteers in order to examine the influence of changes in eating and rest/activity rhythms during Ramadan on the pharmacokinetics of valproic acid (VPA; Depakine(R)). A single oral dose of 800 mg was administered to the first group of subjects (n = 7) at 8.00 PM and to the second group (n = 5) at 5.00 AM. Each group was submitted to three treatment phases: the first was carried out 3 weeks prior to Ramadan (PR), the second one at the end of the first week of Ramadan (R1) and the last at the end of the third week of Ramadan (R3). The plasma kinetics of VPA were determined for each treatment schedule throughout the 50 h following drug intake. During Ramadan, a significant decrease was observed in the C-max (56.22 +/- 5.32 mg/l in Pr vs. 48.35 +/- 5.07 mg/l in R3; p < 0.05) and in the Auc((0-50) h) (1429.92 +/- 284.23 in Pr vs. 1090.26 +/- 277.73 mg.h/l in R3; p < 0.05) for the 8.00 PM intake. For the 5.00 AM intake, a significant decrease was observed in the t 1/2 (12.15 +/- 1.45 h in PR vs. 9.55 +/- 1.97 h in R3; p < 0.05) and AUC((0-50)h) values (1241.29 +/- 239.01 mg.h/l in PR vs. 1019.21 +/- 256.86 mg.h/l in R3; p < 0.05). These parameters showed a significant decrease at the end of the third week of Ramadan (R3), compared to the control period (PR). (C) 2000 Prous Science. All rights reserved.

引用

页码：109 / 114

页数：6

共 18 条

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