Synthesis of conformationally constrained phenylalanine analogues via 7-, 8- and 9-endo Heck cyclisations

被引:85
作者
Gibson, SE [1 ]
Guillo, N [1 ]
Middleton, RJ [1 ]
Thuilliez, A [1 ]
Tozer, MJ [1 ]
机构
[1] JAMES BLACK FDN,LONDON SE24 9JE,ENGLAND
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 04期
关键词
D O I
10.1039/a605286j
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The novel conformationally constrained phenylalanine analogues 2,3,4,5-tetrahydro-1N-3-benzazepine-2-carboxylic acid (Sic) 1,1,2,3,4,5,6-hexahydro-3-benzazocine-2-carboxylic acid (Hic) 2 and 2,3,4,5,6,7-hexahydro-1N-3-benzazonine-2-carboxylic acid (Nic) 3 have been synthesised from commercially available 2-iodobenzyl alcohol in 20, 18 and 22% overall yield respectively via 7-, 8 and 9-endo Heck cyclisations.
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页码:447 / 455
页数:9
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