What are the limits to the size of effective dynamic combinatorial libraries?

被引：48

作者：

Corbett, PT ^{[1
]}

Otto, S ^{[1
]}

Sanders, JKM ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 11期

关键词：

D O I：

10.1021/ol049398k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using simple computer simulations of model dynamic combinatorial libraries, we show that the best binders can be amplified to useful concentrations in libraries containing 10-10(6) compounds.

引用

页码：1825 / 1827

页数：3

共 11 条

[1]

CORBETT PT, IN PRESS CHEM EUR J

[2] Adaptive behavior of dynamic combinatorial libraries generated by assembly of different building blocks [J].

Grote, Z ;

Scopelliti, R ;

Severin, K .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (32) :3821-3825

[3] Masterpiece copolymer sequences by targeted equilibrium-shifting [J].

Moore, JS ;

Zimmerman, NW .

ORGANIC LETTERS, 2000, 2 (07) :915-918

[4] Selection and amplification of hosts from dynamic combinatorial libraries of macrocyclic disulfides [J].

Otto, S ;

Furlan, RLE ;

Sanders, JKM .

SCIENCE, 2002, 297 (5581) :590-593

[5]

Otto S, 2003, CURR OPIN DRUG DISC, V6, P509

[6] Dynamic combinatorial chemistry [J].

Otto, S ;

Furlan, RLE ;

Sanders, JKM .

DRUG DISCOVERY TODAY, 2002, 7 (02) :117-125

[7] Recent developments in dynamic combinatorial chemistry [J].

Otto, S ;

Furlan, RLE ;

Sanders, JKM .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (03) :321-327

[8] Chemical biology of dynamic combinatorial libraries [J].

Ramström, O ;

Bunyapaiboonsri, T ;

Lohmann, S ;

Lehn, JM .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2002, 1572 (2-3) :178-186

[9]

Rowan SJ, 2002, ANGEW CHEM INT EDIT, V41, P898, DOI 10.1002/1521-3773(20020315)41:6<898::AID-ANIE898>3.0.CO

[10]

2-E

← 1 2 →