Toxicological considerations of Kampo medicines in clinical use

被引：19

作者：

Ikegami, F

Fujii, Y

Satoh, T

机构：

[1] Chiba Univ, Ctr Environm Hlth & Field Sci, Kashiwa, Chiba 2770882, Japan

[2] Tsumura & Co, Chiyoda Ku, Tokyo 1028422, Japan

[3] Biomed Res Inst, Shiroi 2701402, Japan

来源：

TOXICOLOGY | 2004年 / 198卷 / 1-3期

关键词：

Kampo medicine; Japanese herbal medicine; crude drug; clinical use; toxicity; interaction;

D O I：

10.1016/j.tox.2004.01.029

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Kampo (Japanese herbal) medicines, produced by combining multiple crude drugs, almost all of plant origin but with some of animal or mineral origin, contain great many substances. Since Kampo medicine results from the combination of many substances, their effect is a combination of the various interactions of the constituent substances. It has been demonstrated that several potential side effects such as allergic reactions, diarrhea and vomiting may be experienced when administering Kampo medicine. In addition, it has been reported that Kampo medicine may have antagonistic or synergistic interactions with western drugs or with some foods such as grapefruit juice. Among the 210 medicinal prescriptions used in present-day Japan, the clinical uses and the acute, chronic and mutagenic toxicity of some Kampo medicines are described. Studies of some potential interaction between Kampo medicines and western drugs are also considered. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：221 / 228

页数：8

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