Variation in the Shiga toxin region of 20th-century epidemic and endemic Shigella dysenteriae 1 strains

被引：6

作者：

Greco, KM ^{[1
]}

McDonough, MA ^{[1
]}

Butterton, JR ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2004年 / 190卷 / 02期

关键词：

D O I：

10.1086/421706

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Shiga toxin (Stx) region of Shigella dysenteriae 1 lies on a defective prophage homologous to lambdoid bacteriophages in Stx-producing Escherichia coli. S. dysenteriae 1 strains obtained in locations throughout the world over the course of the past 60 years were assessed for variations in the Stx region by use of polymerase chain reaction and sequence analysis. The defective prophage was present in all strains examined, suggesting that all S. dysenteriae 1 isolates derive from a clone that resulted from a single phage-integration event. All western-hemisphere strains have an additional iso-IS1 insertion element upstream of stxAB, implying that there has been minimal exchange of strains between hemispheres in recent decades.

引用

页码：330 / 334

页数：5

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