Vibrational spectrometry for the assessment of active substance in metoprolol tablets: A comparison between transmission and diffuse reflectance near-infrared spectrometry

被引:85
作者
Gottfries, J [1 ]
Depui, H [1 ]
Fransson, M [1 ]
Jongeneelen, M [1 ]
Josefson, M [1 ]
Langkilde, FW [1 ]
Witte, DT [1 ]
机构
[1] AB HASSLE,PHARMACEUT R&D,ANALYT CHEM & PHARMACEUT,S-43183 MOLNDAL,SWEDEN
关键词
diffuse reflectance; multivariate calibration; NIR spectrometry; tablets; transmission;
D O I
10.1016/0731-7085(96)01800-6
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Near-infrared spectrometry (NIR) was used to quantify metoprolol succinate in controlled release tablets. Metoprolol tablets were made accordingly to an experimental design using different strengths around a central strength of 47.5 mg per tablet. A comparison was made between NIR in the diffuse reflectance mode and the transmission mode. This showed that, although a narrower wavelength range was available in the transmission mode, predictions were much better for models based on transmission spectra than for models based on diffuse reflectance spectra. The main reason for this is that in the reflectance mode NIR spectrometry is very sensitive to the inhomogeneity of the material, while in the transmission mode this problem is less severe. This is due to the larger volume of the material scanned in the transmission mode compared to that in diffuse reflectance. Spectra were taken before and after the tablets were stored under humid conditions. This allowed the final calibration models to be made more robust towards variations in the amount of water in the tablet. Different batches of metoprolol pellets and microcrystalline cellulose were used during the production of the tablets. This resulted in models that were more robust towards possible batch-to-batch differences in the main constituents.
引用
收藏
页码:1495 / 1503
页数:9
相关论文
共 21 条
[1]  
[Anonymous], 1993, J NEAR INFRARED SPEC, DOI DOI 10.1255/jnirs.25
[2]  
[Anonymous], 1989, MULTIVARIATE CALIBRA
[3]   CONTROL ANALYSIS OF A PHARMACEUTICAL PREPARATION BY NEAR-INFRARED REFLECTANCE SPECTROSCOPY - A COMPARATIVE-STUDY OF A SPINNING MODULE AND FIBER OPTIC PROBE [J].
BLANCO, M ;
COELLO, J ;
ITURRIAGA, H ;
MASPOCH, S ;
DELAPEZUELA, C ;
RUSSO, E .
ANALYTICA CHIMICA ACTA, 1994, 298 (02) :183-191
[4]  
BOX GEP, STATISTICS EXPT
[5]   NEAR-INFRARED METHODS FOR THE IDENTIFICATION OF TABLETS IN CLINICAL-TRIAL SUPPLIES [J].
DEMPSTER, MA ;
JONES, JA ;
LAST, IR ;
MACDONALD, BF ;
PREBBLE, KA .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1993, 11 (11-12) :1087-1092
[6]   THE INFLUENCE OF DATA PREPROCESSING ON THE ROBUSTNESS AND PARSIMONY OF MULTIVARIATE CALIBRATION MODELS [J].
DENOORD, OE .
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 1994, 23 (01) :65-70
[7]   NONDESTRUCTIVE NEAR-INFRARED ANALYSIS OF INTACT TABLETS FOR DETERMINATION OF DEGRADATION PRODUCTS [J].
DRENNEN, JK ;
LODDER, RA .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1990, 79 (07) :622-627
[8]  
HALL JW, 1992, CLIN CHEM, V38, P1623
[9]  
Herschel W., 1800, PHILOS T ROYAL SOC A, V90, P255, DOI DOI 10.1098/RSTL.1800.0014
[10]   DEVELOPMENT AND TRANSFERABILITY OF NEAR-INFRARED METHODS FOR DETERMINATION OF MOISTURE IN A FREEZE-DRIED INJECTION PRODUCT [J].
JONES, JA ;
LAST, IR ;
MACDONALD, BF ;
PREBBLE, KA .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1993, 11 (11-12) :1227-1231