Molecular investigation of an outbreak of multidrug-resistant Acinetobacter baumannii, with characterisation of class 1 integrons

被引：32

作者：

Kraniotaki, Eleni

Manganelli, Riccardo

Platsouka, Evangelia

Grossato, Anna

Paniara, Olga

Palu, Giorgio

机构：

[1] Evangelismos Med Ctr, Dept Clin Microbiol, Athens 10676, Greece

[2] Univ Padua, Dept Histol Microbiol & Med Biotechnol, Padua, Italy

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2006年 / 28卷 / 03期

基金：

俄罗斯科学基金会;

关键词：

Acinetobacter baumannii; outbreak; multidrug resistance; class; 1; integrons;

D O I：

10.1016/j.ijantimicag.2006.04.016

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We investigated a multidrug-resistant Acinetobacter baumannii outbreak in the Intensive Care Unit (ICU) of a tertiary care hospital in Greece over a 3-month period. Molecular typing of the outbreak isolates from 31 patients revealed that two distinct genotypes were involved. Nine isolates. belonging to both genotypes, were resistant to carbapenems. Samples from the ICU environment and from the hands of personnel were collected to identify possible contamination. Class 1 integrons of 3.1, 2.5 and 2.2 kb were amplified from the clinical and environmental isolates. The 3.1 kb integron carrying five gene cassettes was found for the first time in A. baumannii. The outbreak ceased after implementation of hygienic measures in the ICU, including complete cleaning and disinfection. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

收藏

页码：193 / 199

页数：7

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