EAE: An immunologist's magic eye

被引：103

作者：

Krishnamoorthy, Gurumoorthy ^{[1
]}

Wekerle, Hartmut ^{[1
]}

机构：

[1] Max Planck Inst Neurobiol, Dept Neuroimmunol, D-82152 Martinsried, Germany

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 08期

关键词：

Animal models; Autoimmunity; EAE; MS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; T-CELL-RECEPTOR; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; TRANSGENIC MOUSE MODEL; ABH H-2A(G7) MICE; MULTIPLE-SCLEROSIS; BASIC-PROTEIN; PROTEOLIPID PROTEIN;

D O I：

10.1002/eji.200939568

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

EAE comes in many shapes and colors. Individual variants of EAE present a baffling complexity of different aspects and traits, clinical, immunological, and structural. But, embedded in this seemingly chaotic image, the educated eye will discern patterns that retrace fundamental features of immune response, in particular, autoimmunity and self-tolerance. EAE and its variants thus can be likened to an auto-stereogram, i.e. they are an immunologist's magic eye.

引用

页码：2031 / 2035

页数：5

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