Selective differential spectrophotometric methods for determination of niclosamide and drotaverine hydrochloride

被引:37
作者
Daabees, HG [1 ]
机构
[1] Univ Alexandria, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt
关键词
differential (Delta Alpha); second and third derivative (Delta D-2; Delta D-3); niclosamide; drotaverine hydrochloride; spectrophotometry; selectivity studies;
D O I
10.1080/00032710008543080
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Differential (Delta A), second derivative (Delta D-2) and third derivative (Delta D-3) differential ultraviolet spectrophotometric methods have been presented for the quantitation of niclosamide and drotaverine hydrochloride in pure forms and in their pharmaceutical formulations. For niclosamide, the method is based on measuring Delta Delta A, Delta Delta D-2, Delta Delta D-3 of niclosamide in alkaline solutions against their neutral ethanolic solutions as blanks. For drotaverine hydrochloride, the acidic solutions of the drug are measured against their alkaline solutions as blanks. The proposed methods are sensitive, highly specific and advantageous over the conventional UV assays, since the interference of the excipients, impurities, degradation products or other accompanying drugs is nullified. Accuracy of the analysis with the proposed procedures is significantly greater than the classical spectrophotometric methods.
引用
收藏
页码:639 / 656
页数:18
相关论文
共 24 条
[1]  
Abdel Fattah S. A., 1997, SPECTROSC LETT, V30, P795
[2]  
ABOUNASSIF MA, 1989, J PHARM BELG, V44, P329
[3]  
AMER MM, 1982, J ASSOC OFF ANA CHEM, V65, P894
[4]  
BOLAGI OO, 1993, J CHROMATOGR-BIOMED, V8, P133
[5]   ASSAY OF BENZENOID DRUGS IN TABLET AND CAPSULE FORMULATIONS BY 2ND-DERIVATIVE ULTRAVIOLET SPECTROPHOTOMETRY [J].
DAVIDSON, AG ;
HASSAN, SM .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1984, 73 (03) :413-416
[6]  
EMARA LH, 1993, J AOAC INT, V76, P847
[7]  
FULOP M, 1986, MAGY KEM FOLY, V92, P468
[8]  
GEHER J, 1988, J PHARM BIOMED ANAL, V6, P6
[9]   ION-PAIR REVERSED-PHASE LIQUID-CHROMATOGRAPHIC IDENTIFICATION AND QUANTITATION OF PAPAVERINE CONGENERS [J].
GIRGIS, EH .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1993, 82 (05) :503-505
[10]  
KNAUB V A, 1989, Farmatsiya (Moscow), V38, P46